American Journal of Clinical Case Reports (ISSN: 2766-8347)

The American Journal of Clinical Case Reports (AJCCR) – (ISSN: 2766-5844) is an international, open-access, peer-reviewed journal committed to publishing clinically significant case reports from all medical specialties. Our focus is on real-world cases that offer unique insights into diagnosis, treatment, and patient outcomes.

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The American Journal of Clinical Case Reports (AJCCR) – (ISSN: 2766-5844) is an international, open-access, peer-reviewed journal committed to publishing clinically significant case reports from all medical specialties. Our focus is on real-world cases that offer unique insights into diagnosis, treatment, and patient outcomes. AJCCR welcomes rare presentations, unexpected complications, and novel management approaches that contribute to evidence-based clinical practice. We aim to serve as a global platform for physicians, residents, and healthcare professionals to share and learn from patient-centered experiences. All accepted articles are assigned a DOI and indexed for broad academic visibility.

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Recently Published Articles

Am J Clin Case Rep. 2025;6(1):1101 | Open Access | Case Report

Pancytopenia Induced by Endocrine Dysfunction Following Craniopharyngioma Resection

Stein M, Ibrahim A, Kadamov Y and Chelliah T

Pancytopenia is a rare but reversible complication of endocrine dysfunction. We present a case of a 59-year-old female with adrenal insufficiency and hypothyroidism secondary to ...

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Am J Clin Case Rep. 2025;6(1):1105 | Open Access | Case Report

Displaced Proximal Humerus Fracture in an Adolescent Following a Rugby Injury

Shaza Ali, Humayun Hijazi and Eoin Sheehan

A teenage boy was referred with a proximal humerus fracture after he injured his shoulder while participating in a rugby match. The initial imaging studies ...

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Am J Clin Case Rep. 2025;6(1):1102 | Open Access | Case Report

Uterine Malformations Discovered Incidentally During Emergency Caesarean Sections in Full-Term Pregnancies in the Northeastern Part of the Democratic Republic of Congo: About 3 Cases and Review of the Literature

Alain BM, Faustin MV, Daniel EM, Wasingya DK, Claude KM and Sévérin UA

Introduction: Uterine malformations, or Mullerian anomalies, are secondary to the absence of migration or incomplete caudal migration, or a defect in the fusion of the ...

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Am J Clin Case Rep. 2025;6(1):1103 | Open Access | Case Report

A Successful Application of NGS-guided Precision Medicine in Ewing Sarcoma in Iran: A Case Report

Shahdad Farokhmanesh, Omid Reza Zekavat, Mohammadreza Bordbar, Golsa Shekarkhar, Mahdi Shahriari, Hadi  Mottaghipisheh  and Ramin Ajami

Background: Ewing sarcoma is a rare, aggressive malignancy of bone and soft tissue, primarily affecting adolescents and young adults. Even with access to standard ...

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Am J Clin Case Rep. 2025;6(1):1100 | Open Access | Case Report

Acute Limb Ischaemia Following Delayed Coil Migration After Embolization of A Common Femoral Artery Aneurysm: A Case Report

Eng C and Hamish M

Background: Endovascular coil embolization is a minimally invasive technique widely used for managing aneurysms. While effective, complications such as coil
migration are rare but ...

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Am J Clin Case Rep. 2025;6(1):1099 | Open Access | Case Report

Melorheostosis of the Knee: A Rare Cause of Chronic Pain and Functional Impairment in a Young Adult Male

Ali SNO, Hijazi H and Sheehan E

This case report discusses few aspects of melorheostosis in a male patient in early thirties with several years of progressive knee  pain and stiffness, ...

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Am J Clin Case Rep. 2025;6(1):1098 | Open Access | Case Report

A Case Report: Systemic-Onset Juvenile Idiopathic Arthritis Complicated by Peripheral Gangrene in A 9-Year-Old Girl

Karabuga V, Gurler B, Diarra MF, Yazgan H and Diallo A

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disorder that can lead to a range of complications in children. Vasculitis is a rare but severe ...

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Am J Clin Case Rep. 2025;6(1):1097 | Open Access | Case Report

Breast Cancer Tumoral Heterogeneity: A Case Report of the Discovery of Multiple Heterogeneous Foci of Invasive Carcinoma Arising Within the Right Breast

Lien C, Gilbert J, Velazquez C and Margheim B

We report the case of a 50-year-old female with bilateral breast implants who presented with indeterminate, pleomorphic, linear, branching ductal calcifications in the right breast. ...

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Am J Clin Case Rep. 2025;6(1):1096 | Open Access | Research Article

Diaphragmatic Clear Cell, Carcinoma Associated with Endometriosis: Second Case Report and Literature Review

Gómez de la Rosa AG, Quesada López-Fe AA, Vilar Chesa M, Pérez Álvarez JA, Concepción Martín V, Garrido Carrasco M4, Pantoja Ortiz V, Preckler Peña DJ, Sánchez-Pinto Hernández C, Moreno Duque D, Suárez Díaz M and Boria Alegre F

Endometriosis is a chronic, inflammatory gynecological condition that can undergo malignant transformation and was first described in 1925. While endometriotic implants are most commonly located in ...

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Am J Clin Case Rep. 2024;5(3):1095 | Open Access | Case Report

A Rare Case of Parotid Gland Lipoma

Ibtissam L , Naanani O, Loudghiri M, Bijou W, Rouadi S, Abada RL, Roubal M and Mahtar Mb

It is quite uncommon for lipomas to occur in the parotid region. We present a novel case and evaluate the literature for a 59-year-old deaf-dumb ...

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Am J Clin Case Rep. 2024;5(2):1094 | Open Access | Case Report

Benign Oral Lesions, Rare in Newborns: Fordyce Granules

María Elena Venegas Lorena Velandiaand Daniela Moreno

Background: In neonatology and pediatrics, doctors conduct the initial assessment of a newborn’s oral health, which is crucial in differentiating between ...

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Am J Clin Case Rep. 2024;5(2):1093 | Open Access | Case Report

Abducent Nerve Palsy in Herpes Encephalitis: A Case Report

Rashmi Rajur and Shivanand Pai

We describe a case of 50-year-old male who developed a sixth nerve palsy after the diagnosis of herpes encephalitis. Neuroimaging showed medial temporal lobe hyperintensities. ...

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Am J Clin Case Rep. 2024;5(2):1092 | Open Access | Research Article

Role of Tirzepatide in the Management of Type 2 Diabetes and Obesity

Suha Albahrani

Tirzepatide is a GIP-analogue that activates both the GLP-1 and GIP receptors, leading to improved blood sugar control in addition to favorable weight loss effect. ...

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Am J Clin Case Rep. 2024;5(2):1091 | Open Access | Opinion

The COVID-19 Vaccine

Mihnea Orza

1.COVID-19 was created in a laboratory, through repeated sequencing – therefore, it was not created by nature, but artificially based on mutated viruses. <...

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Am J Clin Case Rep. 2024;5(2):1090 | Open Access | Case Report

Delayed Neutropenia Following Single Agent Adjuvant Nivolumab for Melanoma

Haadi A Ali , Nathaniel R, Wilson and Leslie A Fecher

Nivolumab in combination with ipilimumab is standard of care for metastatic melanoma. While immunotherapy provides a survival benefit, it is associated with immune related adverse ...

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Am J Clin Case Rep. 2024;5(1):1089 | Open Access | Case Report

Disseminated CMV Infection Associated Hemophagocytic Lymphocytosis in an Iatrogenic Immunocompromised Host

Haadi Ali , Jawad Bouhamdan, Madison Butler, Nathaniel R Wilson, Nathaniel Christian-Miller and Asra Ahmed

Hemophagocytic Lymphohistiocytosis (HLH) is a rare hematological condition that presents as a sequela of an underlying pathological process CMV has been documented to be a ...

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Am J Clin Case Rep. 2024;5(1):1088 | Open Access | Case Report

Camphor: A Common Substance, An Uncommon Cause of Seizure

Varoon Vadodaria and Shivananda Pai

Camphor, a readily available substance, presents itself as a colourless or white crystalline powder or cubes, characterized by a potent mothball-like fragrance. Possessing a density ...

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Am J Clin Case Rep. 2024;5(1):1087 | Open Access | Case Report

Toxoplasmosis of the Central Nervous System in the Late Period after Transplantation

Barbara Piekarska , Anna Zawiasa-Bryszewska, Anetta Barczak, Magdalena Pawlak , Anna Piekarska and Ilona Kurnatowska

Background: Cerebral toxoplasmosis is extremely rare in Kidney transplant (KTx) recipients. In most reported cases, infection is activated in the early postoperative ...

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Am J Clin Case Rep. 2024;5(1):1086 | Open Access | Research Article

Clinical Characteristics, Treatment and Outcome of Gunshot Injuries in South West Region of Cameroon

Ngomba Divine Martin Mokake,, Nkemnguatem Nelson Atabong , Ekani Boukar , Ekwa Monono Yawa , Nana Theophile , Ngwane Ntongwetapem , Esembeson Malika , Nalova Mwambo , Chichom Meferi Alain and Ngowe Ngowe Marcelin

Background: Gunshot injuries have been on the rise in the south west region of Cameroon for the past 6 years due to the current ...

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Am J Clin Case Rep. 2024;5(1):1085 | Open Access | Case Report

Case Report on Rare Co-Occurrence of Complicated Acute Appendicitis and Ovarian Cyst Rupture

Nurhussen Mossa Ahemd, Alemu Dima Jirru, Terefayehu Belay Hailu and Sitotaw Mossa Ahmed

Acute appendicitis is the most common surgical emergency, and is also the most common cause of non-gynecological pelvic pain. Female patients presenting with abdominal pain ...

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